Ambridgeshire, CB10 1SD, UK, 9 Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA, 10 Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901, USA, 11 Luxembourg University Luxembourg Centre for Systems Biomedicine, 4362 Belval, Luxembourg, 12 CMBI, NCMLS, Radboudumc Nij